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Ipsen grants amazing H1 2021 effects and improvements Full-12 months counsel

PARIS, July 29, 2021--(business WIRE)--Regulatory information:

Ipsen (Euronext: IPN; ADR: IPSEY), a worldwide strong point-driven biopharmaceutical business, today announced its fiscal outcomes for the primary half of 2021:

David Loew, Chief executive Officer, commented:"Our amazing results mirrored the progress we're making with our new method. We continued to grow our manufacturers, with above all amazing revenue within the 2nd quarter partly a result of the gradual lifting of pandemic confinement measures. We executed the vital regulatory approval and launch of the mixture of Cabometyx® with nivolumab in first-line renal cellphone carcinoma and, whereas we had been dissatisfied with the accurate phase III records readout in liver melanoma, our pipeline endured to beef up, with the tremendous section III results for Cabometyx® in thyroid melanoma and the regulatory submission of palovarotene in FOP. This progress turned into coupled with contemporary licensing agreements in the early and mid-stage pipeline. i was also completely happy with the efficiencies performed right through our business, with the focus on our way of life additionally underpinning extra interesting alternatives to improvement sufferers and society.

Story continues

Our raised expectations for our full-12 months outcomes mirror the electricity of our enterprise. in the close term, we await additional regulatory steps for palovarotene within the U.S. and Europe, while we continue to assume launches of standard lanreotide in Europe this 12 months. I expect Ipsen to continue to convey, driven by a transparent strategy, strong fundamentals and attractive increase opportunities, reinforced by way of an unrelenting focal point on serving patients."

evaluate of results5

H1 2021

€m

trade

genuine

CER6

total sales

1,350.three

6.5%

eleven.0%

forte Care

1,244.5

6.6%

11.2%

buyer Healthcare

one hundred and five.9

four.7%

8.6%

Core working earnings

479.eight

17.0%

Core working margin

35.5%

3.2% features

Core Consolidated net earnings

359.8

21.2%

Core EPS7 (thoroughly diluted)

€4.31

21.3%

IFRS working salary

412.2

65.0%

IFRS operating margin

30.5%

10.8% features

IFRS Consolidated net earnings

303.three

36.2%

IFRS EPS (fully diluted)

€three.64

36.5%

  • total sales boom in H1 2021 of 11.0% at CER6, or 6.5% as reported, to €1,350.3m. This covered an increase in strong point Care sales of eleven.2percent6 to €1,244.5m, pushed by the boom of Cabometyx®, Decapeptyl® (triptorelin), Somatuline® (lanreotide) and Dysport® (botulinum toxin class A). purchaser Healthcare revenue growth of eight.6%6 to €one zero five.9m changed into partly a result of the decreasing outcomes of the COVID-19 pandemic, specifically in China

  • Core working income of €479.8m, up with the aid of 17.0%, partly mirrored the potent growth in complete revenue and different revenue. The boost in SG&A expenses to €483.4m was restricted to 3.0%, with cost savings realized in selling costs, due to the decreased travel, the entire impact of virtual conferences and clinical conferences, as well as efficiency beneficial properties from procurement rate reductions, task prioritization, digital initiatives and manufacturing optimization

  • Core operating margin of 35.5%, a rise of three.2 percent facets versus the first half of 2020

  • Core consolidated web profit of €359.8m, with increase of 21.2% reflecting the aforementioned enhance in core working income. Core EPS (utterly diluted) grew through 21.three% to attain €4.31

  • IFRS working revenue of €412.2m after amortization of intangible assets, impairment losses and other operating costs. An IFRS operating profits margin of 30.5% represented a rise of 11 percent facets compared to H1 2020, when an impairment loss on the intangible belongings of palovarotene turned into identified, following termination of the MO-Ped section II trial

  • IFRS consolidated internet profit of €303.3m represented a rise of 36.2%. IFRS EPS (wholly diluted) became up through 36.5% to €3.sixty four

  • Free cash move of €291.4m represented a rise of 24.9%, certainly pushed through larger working cash flow and a discount in present revenue tax

  • Closing net debt came to €336.5m (H1 2020: €923.3m), with the development in H1 2021 primarily reflecting the technology of free money flow

  • FY 2021 guidanceThe enterprise nowadays upgrades its monetary suggestions for FY 2021, which contains an assumed revolutionary international restoration from COVID-19 within the second half of the year. Subsequent to the July 2021 launch of ordinary lanreotide in Germany, further launches of regular lanreotide in Europe in the 2d half of the 12 months are additionally assumed; Ipsen does not, besides the fact that children, assume the launch of octreotide or lanreotide generics in the U.S. in 2021.

    complete earnings

    growth enhanced than 8.0%8

    Core working margin

    around 32.0%9, except for any talents have an impact on ofincremental investments from exterior innovation

    currency impactBased on the stage of exchange prices on the end of June 2021, Ipsen anticipates an opposed affect of about 2% from currencies on total earnings in FY 2021.

    research and construction updateIn may additionally 2021, Ipsen introduced that its New Drug software for palovarotene had been permitted by using the U.S. meals and Drug Administration (FDA). Palovarotene is an oral, investigational, selective RARγ agonist for the prevention of heterotopic ossification (new bone formation). The goal regulatory action date assigned by way of the FDA below priority evaluation popularity is 30 November 2021. identical functions were approved by way of the eu medicines agency and Swissmedic.

    during the period, Ipsen introduced that it could endeavor its alternative to collaborate with Exelixis on the COSMIC-311 part III pivotal trial of Cabometyx® in patients with prior to now treated radioactive iodine-refractory differentiated thyroid melanoma. Ipsen has an unique collaboration agreement with Exelixis for the commercialization of Cabometyx® outside the U.S. and Japan.

    In June 2021, Ipsen and Exelixis introduced that COSMIC-312, the continuing pivotal phase III trial evaluating Cabometyx® in mixture with atezolizumab, versus sorafenib in sufferers with previously untreated superior hepatocellular carcinoma, met some of the primary endpoints, demonstrating giant growth in development-free survival (PFS) on the deliberate fundamental analysis. A prespecified period in-between evaluation for the second fundamental endpoint of overall survival (OS), performed on the identical time as the fundamental analysis for PFS, showed a vogue favoring the aggregate of Cabometyx® and atezolizumab, however did not reach statistical importance. in line with this preliminary OS records, it is anticipated that the chance of accomplishing statistical value at the time of the ultimate evaluation is low.

    enterprise developmentIpsen these days announced two agreements in keeping with its external-innovation center of attention on strengthening the pipeline:

    - BKX-001 (Oncology)In July 2021, Ipsen announced a licensing settlement with BAKX Therapeutics, proposing Ipsen exclusive rights to improve, manufacture and commercialize BKX-001 as a potential remedy for leukemia, lymphoma and solid tumors.

    - Mesdopetam (Neuroscience)past in July 2021, Ipsen also announced a licensing settlement with IRLAB, featuring Ipsen exclusive building and industrial rights to mesdopetam, a novel dopamine D3-receptor antagonist, as a possible treatment option for americans living with Parkinson’s disease experiencing levodopa-induced dyskinesia.

    enterprise Social ResponsibilityIpsen’s CSR focus is on three areas: employees, Communities and atmosphere. Examples of growth in the first half are proven beneath:

    - EmployeesIpsen has established a balanced gender-target ratio for its global leadership team with the aid of 2025. an identical timeframe has been based for the executive management group at at least 35% of each genders.

    - CommunitiesThe enterprise’s revolving credit facility (RCF) includes a key ESG10 element. Favorable outcomes versus ESG-primarily based targets with the aid of Ipsen are rewarded with charitable donations, considered one of which became currently awarded to foreign fitness partners, a charity helping people in one of the vital world’s most difficult areas to get the drug treatments they want.

    - EnvironmentIpsen is now the use of one hundred% green electricity throughout its sites in U.k., eire and France; 88% of Ipsen’s world electrical energy usage is now from renewable sources. The enterprise is also committed to the sustainable consumption of supplies and should continue to raise energy efficiency within its operations.

    conference callA conference name and webcast for traders and analysts will begin at 2:30pm Paris time today. individuals are inspired to dial in to the name early and can register right here; a recording should be available on ipsen.com, while the webcast may also be accessed right here. The event identification is 8026207.

    CalendarThe enterprise intends to publish its year-to-date and third-quarter earnings replace on 21 October 2021.

    NotesAll fiscal figures are in € hundreds of thousands (€m). The efficiency proven during this announcement covers the six-month length to 30 June 2021 (the first half or H1 2021) and the three-month length to 30 June 2021 (the second quarter or Q2 2021), in comparison to six-month length to 30 June 2020 (H1 2020) and the three-month duration to 30 June 2020 (Q2 2020) respectively, unless stated in any other case. Commentary is based on the performance in H1 2021, except pointed out in any other case.

    IpsenIpsen is a worldwide, mid-sized biopharmaceutical company concentrated on transformative medicines in Oncology, infrequent sickness and Neuroscience; it additionally has a well-established consumer Healthcare company. With complete sales of over €2.5bn in FY 2020, Ipsen sells more than 20 drug treatments in over 115 countries, with a right away business presence in more than 30 nations. The company’s research and construction efforts are concentrated on its ingenious and differentiated technological platforms found within the coronary heart of leading biotechnological and life-science hubs: Paris-Saclay, France; Oxford, U.ok.; Cambridge, U.S.; Shanghai, China. Ipsen has around 5,seven hundred colleagues international and is listed in Paris (Euronext: IPN) and in the U.S. through a subsidized level I American Depositary Receipt application (ADR: IPSEY). For more advice, seek advice from ipsen.com.

    total income by way of therapeutic area and product

    H1 2021

    Q2 2021

    €m

    % oftotalsales11

    trade

    €m

    trade

    actual

    CER12

    genuine

    CER12

    total strong point Care

    1,244.5

    92

    6.6%

    11.2%

    632.9

    12.1%

    16.2%

    Oncology

    1,013.1

    75

    four.7%

    8.9%

    517.7

    9.0%

    13.0%

    Somatuline®

    561.4

    42

    -0.1%

    5.2%

    284.5

    2.8%

    8.0%

    Decapeptyl®

    222.5

    sixteen

    15.0%

    16.three%

    116.2

    19.9%

    20.6%

    Cabometyx®

    166.8

    12

    22.0%

    22.9%

    eighty three.6

    29.eight%

    30.2%

    Onivyde®

    fifty seven.8

    4

    -7.6%

    1.5%

    31.3

    -0.1%

    9.9%

    other Oncology

    4.5

    -

    -63.four%

    -sixty three.6%

    2.1

    -60.5%

    -60.9%

    Neuroscience

    205.eight

    15

    20.7%

    28.three%

    102.7

    33.2%

    38.2%

    Dysport®

    202.8

    15

    19.6%

    27.1%

    a hundred and one.0

    31.eight%

    36.6%

    infrequent ailment

    25.6

    2

    -12.0%

    -10.1%

    12.6

    -

    2.0%

    NutropinAq®

    17.0

    1

    -11.2%

    -11.3%

    eight.6

    6.5%

    6.0%

    Increlex®

    8.6

    1

    -13.6%

    -7.7%

    4.0

    -11.7%

    -5.3%

    total purchaser Healthcare

    one zero five.9

    8

    four.7%

    8.6%

    58.9

    19.8%

    23.1%

    Smecta®

    35.7

    3

    -5.6%

    -1.eight%

    19.4

    -2.8%

    0.9%

    Tanakan®

    20.6

    2

    6.2%

    11.8%

    12.1

    31.1%

    34.9%

    Forlax®

    17.2

    1

    -12.8%

    -eleven.2%

    eight.1

    -18.0%

    -16.8%

    Fortrans/Eziclen®

    sixteen.7

    1

    40.9%

    47.6%

    9.9

    ninety seven.6%

    102.0%

    different consumer Healthcare

    15.7

    1

    27.0%

    29.eight%

    9.4

    eighty five.3%

    87.1%

    complete income

    1,350.three

    a hundred

    6.5%

    eleven.0%

    691.8

    12.7%

    16.eight%

    strong point CareSales in H1 2021 amounted to €1,244.5m, a rise of eleven.2p.c12. Oncology and Neuroscience revenue increased by way of 8.9p.c12 and 28.three%12 to €1,013.1m and €205.8m, respectively, while infrequent disorder revenue declined through 10.1%12 to €25.6m.

    distinctiveness Care comprised ninety two% of complete revenue (H1 2020: ninety two%).

    OncologySales of €1,013.1m in H1 2021 represented increase of 8.9p.c12, reflecting persevered market-share beneficial properties in most markets, and a market healing in China underpinned the effective efficiency of Decapeptyl®, whereas there have been additionally respectable results for Cabometyx® and Somatuline® globally.

    Oncology earnings in H1 2021 comprised 75% of complete revenue (H1 2020: seventy six%).

    a) Somatuline® sales reached € 561.four m in H1 2021, an increase of 5.2% 12 , pushed by way of endured market-share good points in most markets and a limited impact from prevalent-octreotide sales in Europe. North the us revenue grew by 3.6% 12 , partly a mirrored image of a robust Q2 2020 performance impacted by way of end-person purchasing patterns; the performance in H1 2021 in North the usa turned into driven through encouraging volumes.

    b) Decapeptyl® sales in H1 2021 of € 222.5 m reflected increase of sixteen.three% 13, specially pushed by means of China, which tremendously recovered from the preliminary impacts in 2020 from COVID-19. The respectable efficiency in France and rest of Asia changed into mirrored with the aid of market-share beneficial properties.

    c) Cabometyx® income in H1 2021 reached € 166.8 m, up by way of 22.9% 13 , pushed by a robust extent uptake throughout most geographies in each renal cellphone carcinoma and hepatocellular carcinoma. Following regulatory approval, Cabometyx®, in combination with nivolumab, was these days launched in Germany as a first-line remedy for sufferers with renal phone carcinoma.

    d) Onivyde® earnings in H1 2021 of € 57.8 m reflected a rise of 1.5% 13 , pushed by means of greater earnings to Ipsen’s ex-U.S. companion, Servier, offset by way of the have an impact on of the pandemic on melanoma remedy within the U.S.

    NeuroscienceDysport® income reached €202.8m in H1 2021, up through 27.1percent13, partly driven via an encouraging healing from the pandemic in most markets, particularly in the second quarter, in addition to a very good efficiency in the North the united states and Europe therapeutics markets and turning out to be aesthetics markets in Turkey, Russia and the middle East. There was additionally a endured strong aesthetics efficiency from Ipsen’s companion, Galderma, in most of its markets.

    Neuroscience earnings comprised 15% of complete revenue in H1 2021 (H1 2020:13%).

    infrequent DiseaseNutropinAq® (somatropin) revenue in H1 2021 of €17.0m, a decline of 11.threep.c13, reflected aggressive pressures throughout Europe. A decline in Increlex® (mecasermin) revenue of 7.7percent13 to €8.6m turned into partly due to the decrease demand in the U.S., reflecting persisted COVID-19 outcomes.

    infrequent disease income in H1 2021 comprised 2% of total sales (H1 2020: 2%).

    buyer HealthcareSales of €one hundred and five.9m in H1 2021 mirrored boom of 8.6%13, with a powerful efficiency complemented by way of a part of phasing and by the forty seven.6percent13 growth of Fortrans/Eziclen® (macrogol 4000) to €16.7m, certainly reflecting the reduced level of revenue in the comparative period, in particular in China. There became additionally an 11.8%13 raise in earnings of Tanakan® (ginkgo biloba extract) to €20.6m, driven by means of an outstanding performance and a excessive level of deliveries in Vietnam. Smecta® (diosmectite) sales declined through 1.8percent13 to €35.7m, with the healing in China offset by way of widespread-medicine power in France.

    customer Healthcare earnings in H1 2021 comprised eight% of complete revenue (H1 2020: 8%).

    total revenue by geographical area

    H1 2021

    Q2 2021

    €m

    exchange

    €m

    change

    specific

    CER14

    exact

    CER14

    foremost Western European nations

    440.7

    6.4%

    6.6%

    223.three

    17.four%

    17.four%

    France

    155.4

    5.eight%

    6.7%

    80.9

    18.8%

    20.1%

    Germany

    102.2

    8.7%

    8.7%

    forty nine.1

    12.2%

    12.2%

    Italy

    sixty five.four

    7.1%

    7.1%

    32.5

    25.5%

    25.5%

    Spain

    59.1

    7.5%

    7.5%

    30.eight

    22.6%

    22.6%

    U.okay.

    fifty eight.6

    2.2%

    1.6%

    30.0

    9.7%

    6.6%

    other European nations

    257.6

    three.four%

    8.0%

    137.0

    17.0%

    20.9%

    japanese Europe

    118.eight

    11.0%

    19.6%

    64.eight

    30.four%

    37.1%

    other Europe

    138.8

    -2.4%

    -0.5%

    seventy two.3

    7.0%

    9.1%

    North america

    403.0

    -3.8%

    4.9%

    196.1

    -3.6%

    5.0%

    relaxation of the realm

    248.9

    33.9%

    38.3%

    135.4

    31.7%

    33.4%

    Asia

    126.3

    66.eight%

    68.6%

    seventy two.4

    64.0%

    65.3%

    other leisure of the realm

    122.6

    eleven.four%

    17.2%

    sixty three.1

    7.four%

    9.7%

    total sales

    1,350.three

    6.5%

    eleven.0%

    691.8

    12.7%

    sixteen.8%

    primary Western European countriesSales in H1 2021 reached €440.7m, a rise of 6.6%14. foremost Western European nations comprised 33% of total sales in H1 2021 (H1 2020: 33%).

    a) France: income of € one hundred fifty five.4 m, a rise of 6.7% 14 , reflected a high-quality restoration from the pandemic with continued market-share positive factors for most area of expertise Care drugs, offset by a low diarrhea market, impacting customer Healthcare.

    b) Germany: income reached € 102.2 m, up by means of eight.7% 14 , above all pushed with the aid of persevered market-share gains for Cabometyx® and Somatuline®, with a constrained have an impact on from the sale of regular octreotide.

    c) Italy: revenue of € 65.four m, up by way of 7.1% 14 , with a superb performance of Cabometyx®, together with an improved buyer Healthcare efficiency.

    d) Spain: revenue of € fifty nine.1 m reflected an increase of 7.5% 14 , pushed via market-share beneficial properties for Somatuline® and Decapeptyl®.

    e) U.k.: earnings reached € 58.6 m, a rise of 1.6% 14 , driven with the aid of strong growth of Somatuline® because of market-share features, partly offset through lessen volumes of Decapeptyl®.

    other European countriesSales in H1 2021 reached €257.6m, up by means of eight.0p.c14, primarily pushed by using larger Dysport® volumes in Russia and Greece, along with successful launches and market-share beneficial properties for Cabometyx®, offset via reduced customer Healthcare revenue in eastern Europe.

    In H1 2021, sales in different European countries comprised 19% of total revenue (H1 2020: 20%).

    North AmericaSales of €403.0m in H1 2021 mirrored growth of four.9p.c15, pushed by way of continued increase of Somatuline®, regardless of an common antagonistic impact from the pandemic on cancer treatment. Dysport® revenue mirrored a superb performance in the aesthetics and therapeutics markets, after the large have an effect on of COVID-19 in H1 2020.

    In H1 2021, earnings in North the us comprised 30% of total sales (H1 2020: 33%).

    leisure of the WorldSales in H1 2021 reached €248.9m, an increase of 38.3percent15, driven by using a China restoration that resulted in effective Decapeptyl® and buyer Healthcare sales. This become accompanied with the aid of a pretty good Dysport® efficiency in Latin the us, Australia and the core East, as well as a superb efficiency from Decapeptyl® in the leisure of Asia.

    In H1 2021, revenue within the leisure of the area comprised 18% of complete revenue (H1 2020: 15%).

    evaluation of core consolidated earnings remark

    Core monetary measures are performance warning signs. A reconciliation between these warning signs and IFRS aggregates is presented in Appendix 4 ‘Bridges from IFRS consolidated internet income to core consolidated net earnings’.

    H1 2021

    €m

    % oftotal revenue

    alternate

    total earnings

    1,350.3

    100%

    6.5%

    different revenue

    sixty four.three

    4.8%

    66.three%

    total revenue

    1,414.6

    104.8%

    8.2%

    can charge of goods bought

    (250.6)

    -18.6%

    3.6%

    selling prices

    (384.three)

    -28.5%

    2.four%

    analysis and building fees

    (207.three)

    -15.four%

    8.8%

    universal and administrative charges

    (ninety nine.1)

    -7.3%

    5.4%

    different core working salary

    6.6

    0.5%

    25.1%

    different core operating charges

    -

    -

    -92.1%

    Core working income

    479.8

    35.5%

    17.0%

    internet financing expenses

    (11.4)

    -0.eight%

    -sixteen.5%

    Core other monetary profits and charges

    (2.5)

    -0.2%

    -seventy eight.eight%

    Core revenue taxes

    (106.three)

    -7.9%

    22.7%

    Share of net income/(loss) from fairness-accounted agencies

    0.1

    -

    -106.0%

    Core Consolidated web earnings

    359.8

    26.6%

    21.2%

    - because of caused by Ipsen SA shareholders

    360.5

    26.7%

    21.7%

    - attributable to non-controlling pastimes

    (0.7)

    -0.1%

    n.a.

    Core EPS (absolutely diluted): brought on by Ipsen SA shareholders (€)

    four.31

    -

    21.three%

    Reconciliation from core consolidated web earnings to IFRS consolidated web income

    H1 2021

    H1 2020

    €m

    €m

    Core Consolidated net income

    359.eight

    297.0

    Amortization of intangible property (excluding utility)

    (30.7)

    (32.0)

    other working salary and prices

    (16.eight)

    (14.2)

    Restructuring costs

    (three.0)

    (10.8)

    Impairment losses

    -

    (58.9)

    Others

    (6.0)

    forty one.7

    IFRS Consolidated net profit

    303.three

    222.7

    IFRS EPS (thoroughly diluted): because of Ipsen SA shareholders (€)

    3.64

    2.66

    total salesTotal earnings grew in H1 2021 by way of 11.0% at CER16, or 6.5% as suggested, to €1,350.3m.

    different revenueOther revenue totaled €sixty four.3m, an increase of 66.three%, reflecting the boom in royalties paid via companions, primarily with the aid of Galderma in appreciate of Dysport®.

    charge of items soldCost of items bought of €250.6m represented 18.6% of complete sales (H1 2020: €241.8m, 19.1%), reflecting increase of three.6%. The favorable mix have an impact on of specialty Care increase endured to pressure a decline within the cost of items sold as a percent of complete sales, regardless of an increase of royalties paid to partners, principally for Cabometyx®.

    selling expensesSelling prices multiplied with the aid of 2.four% to €384.3m, pushed by means of the commercial efforts deployed to help uniqueness Care growth, the healing of actions postponed or cancelled especially because of COVID-19 as smartly because the affect of the enterprise’s effectivity application. promoting fees represented 28.5% of total sales, a decline of one percent element.

    analysis and building expensesResearch and construction fees totaled €207.3m, representing growth of eight.8%. funding in lifecycle management persisted, including in Oncology for Onivyde® and Cabometyx® and in Neuroscience for Dysport®. knowledge new medicines additionally benefited from investment, akin to palovarotene in infrequent disease and subsequent-era neurotoxins in Neuroscience.

    usual and administrative expensesGeneral and administrative prices elevated by 5.4% to €99.1m, chiefly pushed via the reinforcement of the global IT method; the ratio to total income was extensively reliable at 7.three%.

    other core working profits and expensesOther core working salary and costs amounted to an salary of €6.6m (H1 2020 income of €5.1m), essentially reflecting the influence of Ipsen’s foreign money-hedging coverage.

    Core working incomeCore operating revenue amounted to €479.8m, representing increase of 17.0% and comprised 35.5% of total income (H1 2020: 32.three%).

    Core net financing fees and other monetary profits and expenseNet financial charges declined by using sixteen.5% to €11.4m. other core financial expenses of €2.5m reflected a fall of seventy eight.eight%, particularly driven by favorable foreign-trade transformations and reduce hedging fees.

    Core revenue taxesCore salary tax expense of €106.3m, a rise of 22.7%, mirrored a core positive tax price of 22.8% (H1 2020: 22.5%).

    Core consolidated internet profitCore consolidated internet earnings improved by way of 21.2% to €359.8m, with €360.5m fully attributable to Ipsen SA shareholders.

    Core EPSCore EPS (wholly diluted) came to €4.31, representing growth of 21.3%.

    From core fiscal measures to IFRS suggested figures

    Reconciliations between IFRS June 2021 and June 2020 consequences and the Core economic measures are introduced in Appendix four. The leading reconciling objects between core consolidated internet earnings and IFRS consolidated internet profit had been:

    Amortization of intangible belongings (aside from application)Amortization of intangible property (with the exception of utility) within the first half amounted to €41.0m before tax (H1 2020: €forty three.9m).

    other operating income and expenses and restructuring costsOther non-core operating revenue and costs in the first half totaled an cost of €22.7m before tax, basically reflecting Ipsen’s transformation courses, including the discontinuation of deprioritized analysis courses according to the enterprise’s approach (H1 2020: an cost of €19.2m).

    Restructuring costsRestructuring prices within the first half amounted to €4.0m. In H1 2020, restructuring expenses before tax came to €15.4m, above all impacted by way of customer Healthcare transformation tasks and by means of the relocation of the Onivyde® manufacturing website from Cambridge, Massachusetts, U.S. to Signes, France.

    Impairment lossesNo impairment loss or profit turned into identified within the first half. In H1 2020, Ipsen recognized an impairment lack of €eighty one.7m before tax, chiefly on the intangible assets of palovarotene following the determination to terminate the MO-Ped trial related to the dissimilar osteochondromas indication.

    OthersOther financial income and costs in the first half blanketed monetary earnings of €2.6m earlier than tax, chiefly because of the exchange in reasonable cost in equity investments. In H1 2020, different financial profits and charges protected monetary income of €45.0m before tax concerning the Contingent value appropriate (CVR) and milestones’ revaluation for Clementia.

    IFRS economic measures

    working incomeOperating income within the first half totaled €412.2m (H1 2020: €249.8m) with an working margin of 30.5%, up by 11 percent points.

    Consolidated net profitConsolidated internet earnings of €303.3m in the first half represented an increase of 36.2%.

    EPSEPS (utterly diluted) in the first half accelerated by way of 36.5% to €3.sixty four.

    operating segments: core working earnings by therapeutic area

    Segmental counsel is offered in keeping with Ipsen’s two working segments, area of expertise Care and buyer Healthcare. All fees allocated to these two segments are introduced within the key efficiency warning signs. corporate overhead expenses and the impact of the company’s forex-hedging policy aren't allotted to both operating segments.

    Core operating revenue is the indicator used by means of Ipsen to measure operating efficiency and to allocate resources. complete sales, complete earnings and core operating profits are offered through therapeutic enviornment for H1 2021 versus H1 2020 in right here table:

    H1 2021

    change

    €m

    €m

    %

    forte Care

    total revenue

    1,244.5

    seventy seven.3

    6.6%

    complete salary

    1,296.3

    one hundred and one.7

    8.5%

    Core working profits

    570.5

    sixty seven.0

    13.3%

    Core operating margin

    45.eight%

    customer Healthcare

    complete earnings

    one hundred and five.9

    4.7

    4.7%

    total salary

    118.3

    5.9

    5.three%

    Core working revenue

    15.6

    10.0

    179.9%

    Core operating margin

    14.7%

    complete Unallocated

    Core working salary

    (106.2)

    (7.3)

    7.4%

    complete

    complete sales

    1,350.3

    82.0

    6.5%

    complete earnings

    1,414.6

    107.7

    8.2%

    Core working profits

    479.eight

    69.7

    17.0%

    Core operating margin

    35.5%

    In H1 2021, uniqueness Care income grew to €1,244.5m, up by using 6.6% (eleven.2% at CER17), attaining ninety two.2% of total earnings (H1 2020: ninety two.0%). Core operating earnings for distinctiveness Care improved by way of 13.three% to €570.5m, representing forty five.8% of total revenue (H1 2020: forty three.1%). The development reflected the persisted growth of Somatuline® in the U.S. and Europe, Dysport® and Decapeptyl® from COVID-19 restoration, the contribution of Cabometyx®, in addition to a rise in research & building investment and in selling charges.

    client Healthcare earnings in the first half increased by four.7% (eight.6% at CER17) to €one hundred and five.9m. Core operating revenue for purchaser Healthcare amounted to €15.6m, representing 14.7% of total sales (H1 2020: 5.5%), reflecting higher sales that were partly pushed by means of the COVID-19 recuperation in China, better other revenue, coupled with a decline in industrial investments.

    Unallocated core operating profits within the first half amounted to a terrible €106.2m (H1 2020: terrible €ninety eight.9m), partly a result of the reinforcement of the global IT approach, a bit of offset by way of the favorable affect in H1 2021 from the currency-hedging policy.

    net money stream and financing

    Ipsen had a internet debt decline of €188.7m in H1 2021, bringing closing web debt to €336.5m.

    H1 2021

    H1 2020

    €m

    €m

    Opening net money/(Debt)

    (525.three)

    (1,a hundred and fifteen.6)

    Core working earnings

    479.8

    410.2

    Non-cash items

    74.3

    69.four

    exchange in operating working-capital requirement

    (sixty seven.5)

    (sixteen.8)

    (boost)/reduce in different working capital requirement

    (28.7)

    (37.eight)

    web capex (except for milestones paid)

    (58.2)

    (56.3)

    Dividends bought from entities accounted for the use of the fairness formulation

    -

    -

    working money movement

    399.7

    368.7

    different non-core operating salary and expenses and restructuring fees (cash)

    (27.9)

    (15.5)

    fiscal earnings (cash)

    (13.5)

    (24.eight)

    present income tax (P&L, except for provisions for tax contingencies)

    (67.9)

    (99.4)

    other operating money circulation

    0.9

    four.three

    Free cash circulate

    291.four

    233.three

    Distributions paid

    (eighty three.1)

    (83.5)

    internet investments (enterprise construction and milestones)

    7.eight

    (four.four)

    Share buyback

    (5.8)

    (6.1)

    FX on net indebtedness and alter in earn-out

    (22.four)

    forty nine.5

    other

    0.eight

    3.5

    Shareholders Return and exterior boom Operations

    (102.6)

    (41.0)

    exchange in net money/(Debt)

    188.7

    192.three

    Closing internet money/(Debt)

    (336.5)

    (923.3)

    operating cash flowOperating money circulation multiplied by using 8.4% within the first half to €399.7m, driven by means of higher core working salary (up by €69.7m) and higher working-capital requirements.

    Non-cash objects elevated by means of 7.1% in the first half to €seventy four.3m (H1 2020: €sixty nine.4m) and especially blanketed the amortization of exact assets and provisions.

    Working-capital requirements for operating activities within the first half increased by means of €sixty seven.5m (H1 2020: €16.8m), chiefly from bigger alternate receivables. different working-capital necessities accelerated by means of €28.7m within the first half, exceptionally pushed by means of variable compensation payments to colleagues in H1 2021.

    net capital expenditure amounted to €fifty eight.2m in the first half (H1 2020: €56.3m), and peculiarly covered initiatives to boost efficiency at industrial sites within the U.ok. and France, together with company investments in IT and digital projects.

    Free cash flowThe raise in free cash stream in the first half to €291.4m (H1 2020: €233.3m) was specifically a result of better operating cash flow mixed with lessen present revenue tax.

    Shareholders return and external growth operationsIn H1 2021, the distribution payout to Ipsen SA shareholders amounted to €eighty two.9m.

    web investments of €7.8m within the first half especially involving Onivyde®’s business milestones acquired for €20.8m and to the proceeds from the divestiture in fairness-accounted corporations for €21.4m, partly offset via further milestone funds of €33.9m to Exelixis.

    international alternate on web indebtedness and change in earn-out adversely impacted web debt in particular due to a much better USD versus EUR on indebtedness, compared to a favorable have an effect on of €forty nine.5m on internet debt in the first half of 2020, which covered the aforementioned CVR and milestone revaluation in appreciate of Clementia.

    Reconciliation of cash and money equivalents and web cash

    H1 2021

    H1 2020

    €m

    €m

    latest financial belongings (by-product gadgets on financial operations)

    0.2

    0.7

    Closing cash and money Equivalents

    726.1

    420.eight

    Non-current loans

    (550.2)

    (565.6)

    different monetary liabilities (excluding derivative contraptions)18

    (221.1)

    (227.0)

    Non-present financial Liabilities

    (771.three)

    (792.6)

    credit score traces and bank loans

    (150.3)

    (267.9)

    fiscal liabilities (with the exception of spinoff instruments)

    (141.2)

    (284.3)

    latest financial Liabilities

    (291.5)

    (552.2)

    Debt

    (1,062.8)

    (1,344.8)

    net Debt19

    (336.5)

    (923.3)

    analysis of cash

  • On 16 June 2016, Ipsen SA issued €300m in unsecured, seven-yr public bonds

  • On 24 may also 2019, Ipsen SA signed an initial 5-yr RCF of €1.5bn, which become extended in 2020 to may 2025, and in 2021 to can also 2026

  • On 23 July 2019, Ipsen SA also issued $300m via a U.S. private Placement (USPP) in two tranches of seven and 10-yr maturities

  • Ipsen ought to comply with a web debt / EBITDA covenant to stay below three.5 instances at every economic closing in each the RCF and the USPP. The RCF also contains particular indications linked to ESG, assessed yearly

  • Ipsen has totally complied with its covenant ratio for the RCF and the USPP

  • On 30 June 2021, the RCF become utilized for €150.3m and the Ipsen SA issuance software of Negotiable EUropean industrial Paper of €600m became drawn for €one hundred.0m

  • Appendix 1: consolidated earnings statement

    H1 2021

    H1 2020

    €m

    €m

    complete sales

    1,350.3

    1,268.three

    different profits

    sixty four.3

    38.6

    complete income

    1,414.6

    1,306.9

    charge of items bought

    (250.6)

    (241.8)

    promoting fees

    (384.three)

    (375.four)

    research and development costs

    (207.3)

    (one hundred ninety.6)

    regularly occurring and administrative costs

    (99.1)

    (94.0)

    different working revenue

    25.eight

    eight.2

    different operating fees

    (eighty two.9)

    (sixty six.2)

    Restructuring expenses

    (four.0)

    (15.four)

    Impairment losses

    (eighty one.7)

    working revenue

    412.2

    249.8

    funding income

    0.6

    1.1

    Financing prices

    (14.7)

    web financing prices

    (eleven.4)

    (13.6)

    different financial revenue and fees

    0.1

    33.9

    income taxes

    (99.0)

    (forty seven.5)

    Share of net profit/(loss) from equity-accounted businesses

    0.1

    (1.3)

    net earnings (loss) from continuing Operations

    302.1

    221.three

    internet earnings (loss) from discontinued operations

    1.2

    1.4

    Consolidated web income (loss)

    303.three

    222.7

    - as a result of Ipsen SA shareholders

    304.0

    221.9

    - because of non-controlling pursuits

    (0.7)

    0.8

    fundamental EPS, continuing operations (€)

    three.sixty six

    2.65

    Diluted EPS, continuing operations (€)

    three.sixty two

    2.sixty five

    simple EPS, discontinued operations (€)

    0.01

    0.02

    Diluted EPS, discontinued operations (€)

    0.01

    0.02

    basic EPS (€)

    3.67

    2.sixty seven

    Diluted EPS (€)

    three.64

    2.sixty six

    Appendix 2: consolidated steadiness sheet earlier than allocation of net income

    30 June 2021

    31 December 2020

    €m

    €m

    assets

    Goodwill

    604.four

    592.8

    different intangible belongings

    1,142.4

    1,121.1

    Property, plant & device

    645.7

    646.6

    fairness investments

    ninety.3

    eighty four.5

    Investments in fairness-accounted agencies

    13.8

    19.1

    Non-existing financial assets

    24.7

    23.1

    Deferred tax property

    231.0

    247.4

    other non-current property

    four.9

    3.8

    complete non-present assets

    2,757.three

    2,738.four

    Inventories

    232.7

    213.9

    trade receivables

    554.6

    476.2

    existing tax belongings

    91.7

    eighty three.6

    present fiscal belongings

    2.1

    forty eight.9

    different existing belongings

    142.1

    113.7

    cash and cash equivalents

    737.5

    642.5

    property of disposal group classified as held on the market

    3.6

    -

    complete latest assets

    1,764.2

    1,578.8

    total property

    4,521.5

    4,317.2

    equity AND LIABILITIES

    Share capital

    eighty three.8

    83.eight

    extra paid-in capital and consolidated reserves

    2,013.4

    1,546.8

    net income (loss) for the length

    304.0

    548.0

    international alternate transformations

    (14.6)

    (59.6)

    equity attributable to Ipsen SA shareholders

    2,386.6

    2,119.1

    fairness caused by non-controlling pursuits

    1.7

    2.7

    complete shareholders' fairness

    2,388.three

    2,121.7

    Retirement improvement duty

    56.9

    63.7

    Non-current provisions

    49.3

    32.0

    other non-existing monetary liabilities

    771.2

    761.6

    Deferred tax liabilities

    92.1

    79.9

    different non-current liabilities

    forty six.6

    45.1

    total non-existing liabilities

    1,016.1

    982.three

    existing provisions

    42.7

    45.7

    latest financial liabilities

    297.0

    408.6

    change payables

    518.6

    495.2

    existing tax liabilities

    5.6

    10.eight

    different existing liabilities

    241.7

    250.0

    financial institution overdrafts

    11.5

    2.eight

    Liabilities involving belongings held on the market

    total existing liabilities

    1,117.0

    1,213.1

    complete fairness & LIABILITIES

    four,521.5

    4,317.2

    Appendix three.1: consolidated observation of money movement

    30 June 2021

    30 June 2020

    €m

    €m

    Consolidated internet earnings

    303.three

    222.7

    Share of earnings (loss) from equity-accounted businesses

    (0.1)

    4.three

    internet profit (Loss) before Share from equity-Accounted organizations

    303.2

    227.0

    Non-cash and Non-working items:

    - Depreciation, amortization, provisions

    110.3

    116.5

    - Impairment losses covered in operating income and web fiscal earnings

    -

    eighty one.5

    - exchange in reasonable cost of economic derivatives

    2.three

    three.9

    - web positive aspects or losses on disposals of non-existing assets

    1.5

    2.6

    - Unrealized overseas-trade adjustments

    (four.7)

    four.0

    - alternate in deferred taxes

    31.1

    (fifty one.9)

    - Share-based mostly fee price

    18.8

    10.6

    - other non-money items

    (7.6)

    (39.eight)

    cash circulate from working activities before changes in Working-Capital Requirement

    454.9

    354.3

    - (raise)/decrease in inventories

    (15.9)

    (10.2)

    - (raise)/reduce in exchange receivables

    (68.4)

    21.1

    - raise/(lessen) in alternate payables

    16.7

    (27.eight)

    - internet trade in earnings tax liability

    (8.1)

    (2.1)

    - web trade in different operating belongings and liabilities

    (22.1)

    (41.9)

    alternate in Working-Capital Requirement regarding working activities

    (ninety seven.7)

    (60.7)

    internet cash provided (USED) through working actions

    357.2

    293.6

    Acquisition of property, plant & equipment

    (34.1)

    (33.three)

    Acquisition of intangible assets

    (forty four.5)

    (18.3)

    Proceeds from disposal of intangible assets and property, plant & gadget

    0.1

    -

    Acquisition of shares in non-consolidated organizations

    (7.eight)

    (3.2)

    payments to post-employment benefit plans

    (0.7)

    (2.three)

    have an impact on of alterations in the consolidation scope

    21.4

    -

    trade in working capital related to investment actions

    (14.5)

    (7.7)

    different money flow related to funding actions

    2.6

    (1.5)

    web cash provided (USED) with the aid of investment activities

    (seventy seven.6)

    (66.3)

    additional long-term borrowings

    12.2

    5.7

    reimbursement of lengthy-time period borrowings

    (0.7)

    (0.7)

    internet trade in short-term borrowings

    (114.5)

    (55.7)

    Capital raise

    -

    -

    Treasury shares

    (5.8)

    (6.0)

    Distributions paid via Ipsen SA

    (82.9)

    (83.2)

    Dividends paid via subsidiaries to non-controlling hobbies

    (0.2)

    (0.3)

    change in working capital concerning financing activities

    (2.eight)

    (4.9)

    net cash supplied (USED) through FINANCING actions

    (194.6)

    (a hundred forty five.2)

    alternate IN cash AND money EQUIVALENTS

    85.0

    82.1

    OPENING money AND money EQUIVALENTS

    639.6

    339.0

    have an impact on of alternate fee fluctuations

    1.four

    (0.three)

    CLOSING money AND money EQUIVALENTS

    726.1

    420.8

    Appendix three.2: consolidated web cash circulate remark

    H1 2021

    H1 2020

    €m

    €m

    Opening internet money/(Debt)

    (525.3)

    (1,one hundred fifteen.6)

    CORE operating income

    479.eight

    410.2

    Non-cash gadgets

    74.3

    sixty nine.four

    (raise)/decrease in inventories

    (15.9)

    (10.2)

    (boost)/lower in change receivables

    (68.four)

    21.1

    increase/(decrease) in trade payables

    16.7

    (27.8)

    alternate in operating Working-Capital Requirement

    (sixty seven.5)

    (sixteen.8)

    alternate in revenue tax liability

    (8.2)

    (2.1)

    trade in other operating assets and liabilities (apart from milestones got)

    (20.5)

    (35.7)

    different alterations in Working-Capital Requirement

    (28.7)

    (37.8)

    Acquisition of property, plant & device

    (34.1)

    (33.3)

    Acquisition of intangible assets (except milestones paid)

    (10.1)

    (eight.2)

    Disposal of mounted property

    0.1

    -

    exchange in working capital regarding investment actions

    (14.1)

    (14.eight)

    web Capex (with the exception of milestones paid)

    (58.2)

    (fifty six.3)

    Dividends acquired from Entities Accounted for using the equity formulation

    -

    -

    working money move

    399.7

    368.7

    different non-core operating profits and prices and restructuring fees

    (27.9)

    (15.5)

    fiscal income

    (13.5)

    (24.8)

    existing earnings tax

    (sixty seven.9)

    (ninety nine.4)

    other operating cash move

    0.9

    4.3

    Free money circulation

    291.four

    233.3

    Distributions Paid (together with Payout to Non-Controlling pursuits)

    (eighty three.1)

    (83.5)

    Acquisition of shares in non-consolidated companies20

    (7.eight)

    (3.four)

    Acquisition of alternative fiscal belongings

    -

    -

    affect of changes in consolidation scope

    21.four

    -

    Milestones paid21

    (34.9)

    (2.eight)

    Milestones acquired

    25.0

    1.8

    different enterprise-development operations

    four.0

    -

    net Investments (company development and Milestones)

    7.eight

    (4.4)

    Share buyback

    (5.eight)

    (6.1)

    FX on net indebtedness and alter in earn-out

    (22.four)

    49.5

    different

    0.8

    three.5

    Shareholders Return and exterior-increase Operations

    (102.6)

    (41.0)

    change IN net cash/(DEBT)

    188.7

    192.3

    Closing internet money/(Debt)

    (336.5)

    (923.3)

    Appendix 4: bridges from IFRS Consolidated web profit to Core Consolidated internet earnings

    H1 2021

    IFRS

    Core

    H1 2021

    Amortization ofintangible belongings(excl. utility)

    different operatingincome orexpenses

    Restructuring

    Impairmentlosses

    different

    H1 2021

    €m

    €m

    €m

    €m

    €m

    €m

    €m

    complete revenue

    1,350.three

    1,350.3

    other income

    64.three

    sixty four.three

    complete salary

    1,414.6

    1,414.6

    cost of goods bought

    (250.6)

    (250.6)

    selling fees

    (384.3)

    (384.3)

    research and construction charges

    (207.3)

    (207.3)

    time-honored and administrative costs

    (99.1)

    (ninety nine.1)

    other operating salary

    25.eight

    (19.2)

    6.6

    different operating fees

    (eighty two.9)

    41.0

    forty one.9

    Restructuring costs

    (4.0)

    4.0

    Impairment losses

    working revenue

    412.2

    forty one.0

    22.7

    four.0

    479.8

    internet financing fees

    (eleven.four)

    (eleven.four)

    other fiscal earnings and expenses

    0.1

    (2.6)

    (2.5)

    profits taxes

    (ninety nine.0)

    (10.three)

    (5.9)

    (0.9)

    9.8

    (106.three)

    Share of earnings/(loss) from fairness-accounted groups

    0.1

    0.1

    net earnings/(Loss) from continuing Operations

    302.1

    30.7

    16.8

    three.0

    7.2

    359.8

    net profit/(loss) from discontinued operations

    1.2

    (1.2)

    Consolidated net income

    303.three

    30.7

    16.8

    3.0

    6.0

    359.eight

    – brought on by Ipsen SA shareholders

    304.0

    30.7

    sixteen.8

    3.0

    6.0

    360.5

    – as a result of non-controlling pursuits

    (0.7)

    (0.7)

    EPS (utterly diluted): caused by Ipsen SA shareholders (€)

    three.64

    0.37

    0.20

    0.04

    0.00

    0.07

    four.31

    The reconciliation objects between core consolidated net earnings and IFRS consolidated net profit are described in the paragraph ‘From core fiscal measures to IFRS said figures’.

    H1 2020

    IFRS

    Core

    H1 2020

    Amortization ofintangible belongings(excl. software)

    other operatingincome orexpenses

    Restructuring

    Impairmentlosses

    other

    H1 2020

    €m

    €m

    €m

    €m

    €m

    €m

    €m

    complete sales

    1,268.three

    1,268.3

    different revenue

    38.6

    38.6

    complete earnings

    1,306.9

    1,306.9

    charge of items bought

    (241.8)

    (241.8)

    promoting costs

    (375.4)

    (375.four)

    analysis and development expenses

    (a hundred ninety.6)

    (one hundred ninety.6)

    frequent and administrative expenses

    (94.0)

    (94.0)

    other working revenue

    8.2

    (2.9)

    5.three

    different working expenses

    (sixty six.2)

    43.9

    22.2

    (0.2)

    Restructuring prices

    (15.4)

    15.four

    Impairment losses

    (eighty one.7)

    eighty one.7

    operating earnings

    249.eight

    43.9

    19.2

    15.4

    81.7

    410.2

    net financing charges

    (13.6)

    (13.6)

    other financial profits and prices

    33.9

    (45.5)

    (eleven.6)

    earnings taxes

    (forty seven.5)

    (eleven.9)

    (5.0)

    (four.6)

    (22.eight)

    5.2

    (86.6)

    Share of profit/(loss) from fairness-accounted organizations

    (1.three)

    (1.3)

    net income/(Loss) from carrying on with Operations

    221.3

    32.0

    14.2

    10.8

    fifty eight.9

    (40.3)

    297.0

    web income/(loss) from discontinued operations

    1.4

    (1.four)

    Consolidated web income

    222.7

    32.0

    14.2

    10.8

    fifty eight.9

    (forty one.7)

    297.0

    – as a result of Ipsen SA shareholders

    221.9

    32.0

    14.2

    10.8

    58.9

    (forty one.7)

    296.2

    – brought on by non-controlling pastimes

    0.8

    0.8

    EPS (utterly diluted): brought on by Ipsen SA shareholders (€)

    2.66

    0.38

    0.17

    0.13

    0.71

    (0.50)

    3.fifty five

    ahead-looking statementsThe forward-searching statements, targets and goals contained herein are in response to Ipsen’s management method, existing views and assumptions. Such statements contain familiar and unknown dangers and uncertainties that could cause genuine effects, performance or events to vary materially from these predicted herein. all the above hazards could have an effect on Ipsen’s future means to achieve its economic aims, that have been set assuming most economical macroeconomic circumstances according to the suggestions available today. Use of the words ‘believes’, ‘anticipates’ and ‘expects’ and an identical expressions are intended to establish ahead-looking statements, including Ipsen’s expectations concerning future pursuits, together with regulatory filings and determinations. in addition, the goals described during this document were prepared with out thinking of exterior growth assumptions and capabilities future acquisitions, which can also alter these parameters. These goals are in accordance with data and assumptions regarded as cost effective by Ipsen. These objectives depend on conditions or records likely to ensue in the future, and never solely on ancient statistics. genuine outcomes may also go away vastly from these objectives given the incidence of certain risks and uncertainties, above all the indisputable fact that a promising product in early construction part or clinical trial may end up never being launched available on the market or attaining its business targets, particularly for regulatory or competitors explanations. Ipsen have to face or might face competition from customary products that may translate right into a loss of market share. in addition, the research and development system includes several levels each of which comprises the mammoth risk that Ipsen may additionally fail to obtain its aims and be forced to desert its efforts relating to a product in which it has invested large sums. hence, Ipsen cannot make certain that favorable effects bought right through preclinical trials might be Checked because of this all the way through medical trials, or that the outcomes of clinical trials will be satisfactory to exhibit the secure and beneficial nature of the product worried. There can also be no ensures a product will get hold of the crucial regulatory approvals or that the product will show to be commercially a success. If underlying assumptions show inaccurate or risks or uncertainties materialize, exact results can also vary materially from these set forth within the ahead-looking statements. other dangers and uncertainties consist of however are not limited to, accepted trade circumstances and competition; well-known economic elements, including interest expense and currency change price fluctuations; the impact of pharmaceutical business law and fitness care legislations; international tendencies toward fitness care can charge containment; technological advances, new products and patents attained through competitors; challenges inherent in new product construction, including obtaining regulatory approval; Ipsen's skill to precisely predict future market circumstances; manufacturing difficulties or delays; monetary instability of overseas economies and sovereign possibility; dependence on the effectiveness of Ipsen’s patents and other protections for ingenious items; and the exposure to litigation, together with patent litigation, and/or regulatory actions. Ipsen additionally is dependent upon third parties to develop and market some of its items which may potentially generate titanic royalties; these companions may behave in such ways which could trigger harm to Ipsen’s actions and financial consequences. Ipsen can't be certain that its companions will fulfil their duties. It might possibly be unable to reap any benefit from those agreements. A default through any of Ipsen’s companions could generate lower revenues than anticipated. Such situations could have a poor impact on Ipsen’s company, fiscal position or efficiency. Ipsen expressly disclaims any obligation or accomplishing to update or revise any ahead-looking statements, pursuits or estimates contained during this press unencumber to replicate any change in pursuits, circumstances, assumptions or circumstances on which such a statements are based mostly, except so required through relevant legislation. Ipsen’s business is discipline to the chance factors outlined in its registration files filed with the French Autorité des Marchés Financiers. The dangers and uncertainties set out don't seem to be exhaustive and the reader is recommended to refer to Ipsen’s 2020 customary Registration document, obtainable on ipsen.com.

    _________________1 At constant trade fees (CER), which exclude any foreign-alternate impact via recalculating the efficiency for the imperative duration by making use of the trade charges used for the prior length.2 working margin described as a ratio of working revenue to total sales.three Fibrodysplasia ossificans progressiva.four enterprise social responsibility.5 Extract of audited consolidated outcomes. The enterprise’s auditors carried out a restrained review of the money owed.6 Excludes any overseas-exchange influence by using recalculating the efficiency for the vital duration by making use of the alternate fees used for the prior period.7 salary per share.eight At CER, which exclude any foreign-exchange have an effect on by recalculating the performance for the principal length through applying the change rates used for the prior period.9 As a ratio of core operating revenue to complete revenue.10 Environmental, Social, and Governance.11 because of rounding, the sum of percentages may additionally now not conform to totals.12 Excludes any international-change impact by means of recalculating the efficiency for the critical period by applying the alternate fees used for the prior length.13 Excludes any international-exchange influence by recalculating the performance for the imperative duration through applying the alternate charges used for the prior period.14 Excludes any overseas-exchange impact by means of recalculating the performance for the vital length by using making use of the trade charges used for the prior period.15 Excludes any overseas-change influence by using recalculating the efficiency for the imperative period by means of making use of the exchange charges used for the prior length.16 Excludes any foreign-alternate have an effect on by way of recalculating the efficiency for the vital period by means of making use of the change charges used for the prior duration.17 Excludes any international-exchange influence by using recalculating the efficiency for the valuable period by way of applying the alternate charges used for the prior period.18 financial liabilities principally exclude €4.5m in spinoff devices involving business operations (H1 2020: €5.3m).19 spinoff gadgets booked in monetary assets and concerning financial operations, money and cash equivalents, much less bank overdrafts, financial institution loans and different economic liabilities and except for financial-spinoff devices on commercial operations.20 Acquisition of shares in non-consolidated agencies chiefly reflected investments in exterior innovation dollars.21 The milestones paid had been recorded as a rise in intangible property on the consolidation balance sheet. The transactions had been blanketed in the ‘Acquisition of intangible belongings’ line merchandise within the consolidated remark of money flow (see Appendix three.1).

    View source version on businesswire.com: https://www.businesswire.com/information/home/20210728006140/en/

    Contacts

    InvestorsCraig MarksVice President, Investor relations+forty four 7584 349 193

    Adrien Dupin de Saint-CyrInvestor members of the family manager+33 6 64 26 17 forty nine

    MediaGwenan WhiteExecutive vp, Communications and Public Affairs+forty four 7876 391 429

    Fanny AllaireGlobal Communications Director+ 33 6 08 ninety one ninety two fifty five


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